![]() Post-reactivation amnesia for learned fear has now been demonstrated in a range of model organisms, from fish, to crabs, to rats 5. ![]() Gene transcription, RNA translation, and protein synthesis are necessary for reconsolidation and these neurobiological processes enable to fundamentally change a fear memory engram 2, 5. It refers to the idea that reactivation can induce a transient, labile state in a previously stable memory, during which the memory is sensitive to disruption or modification, necessitating a time-dependent process of restablization in order to persist. ![]() Observations of post-reactivation amnesia for learned fear have drastically changed the neuroscience literature on memory by generating a novel and influential conceptual framework, known as memory reconsolidation 1, 2, 3, 4, 5.
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